Use of human embryonic stem cells to model pediatric gliomas with H3.3K27M histone mutation.

Abstract

Over 70% of diffuse intrinsic pediatric gliomas, an aggressive brainstem tumor, harbor heterozygous mutations that create a K27M amino acid substitution (methionine replaces lysine 27) in the tail of histone H3.3. The role of the H3.3K27M mutation in tumorigenesis is not fully understood. Here, we use a human embryonic stem cell system to model this tumor… (More)
DOI: 10.1126/science.1253799

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@article{Funato2014UseOH, title={Use of human embryonic stem cells to model pediatric gliomas with H3.3K27M histone mutation.}, author={Kosuke Funato and Tamara Major and Peter A. W. Lewis and C. D. Allis and Viviane S Tabar}, journal={Science}, year={2014}, volume={346 6216}, pages={1529-33} }