Use of host-like peptide motifs in viral proteins is a prevalent strategy in host-virus interactions.

@article{Hagai2014UseOH,
  title={Use of host-like peptide motifs in viral proteins is a prevalent strategy in host-virus interactions.},
  author={Tzachi Hagai and Ariel Azia and M. Madan Babu and Raul Andino},
  journal={Cell reports},
  year={2014},
  volume={7 5},
  pages={1729-1739}
}
Viruses interact extensively with host proteins, but the mechanisms controlling these interactions are not well understood. We present a comprehensive analysis of eukaryotic linear motifs (ELMs) in 2,208 viral genomes and reveal that viruses exploit molecular mimicry of host-like ELMs to possibly assist in host-virus interactions. Using a statistical genomics approach, we identify a large number of potentially functional ELMs and observe that the occurrence of ELMs is often evolutionarily… CONTINUE READING