Use of high-performance liquid chromatography-mass spectrometry for the study of the metabolism of ranitidine in man.


High-performance liquid chromatography has been used for the qualitative analysis of metabolites and the quantitative analysis of ranitidine in the urine from subjects given oral and intravenous doses of ranitidine. Ranitidine, ranitidine-N-oxide, ranitidine-S-oxide and desmethylranitidine were identified in extracts of the urine obtained by the XAD… (More)


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