Use of heteropolymeric monoclonal antibodies to attach antigens to the C3b receptor of human erythrocytes: a potential therapeutic treatment.

@article{Taylor1991UseOH,
  title={Use of heteropolymeric monoclonal antibodies to attach antigens to the C3b receptor of human erythrocytes: a potential therapeutic treatment.},
  author={Ronald P Taylor and William M. Sutherland and Craig J. Reist and Dennis J. Webb and Edward L. Wright and R H Labuguen},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1991},
  volume={88 8},
  pages={3305-9}
}
We have prepared bispecific, cross-linked monoclonal antibodies (heteropolymers) with specificity for both targeted antigens and the human erythrocyte (RBC) complement receptor. These heteropolymers facilitate binding of target antigens (human IgG and dinitrophenylated bovine gamma globulin) to human RBCs under conditions that either allow or preclude complement activation. Quantitative analyses of this binding agree well with the number of complement receptors per RBC. In vitro "whole-blood… CONTINUE READING

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