Use of haemoglobin adducts for biomonitoring exposure to 1,3-butadiene.

  title={Use of haemoglobin adducts for biomonitoring exposure to 1,3-butadiene.},
  author={Siv M Osterman-Golkar and James A Bond and Jonathan B Ward and Marvin S. Legator},
  journal={IARC scientific publications},
Measurement of specific adducts to haemoglobin can be used to establish the dosimetry of electrophilic compounds and metabolites in experimental animals and in man. Adducts of 1,2-epoxybutene with the N-terminal valine in haemoglobin were determined in male B6C3F1 mice and Sprague-Dawley rats following exposure by inhalation to low concentrations of 1,3-butadiene (0, 2, 10 or 100 ppm, 6 h/day, 5 days/week, 4 weeks; animals killed within 1 h after the last exposure). The adduct level increased… CONTINUE READING