Use of graphitised carbon negative ion LC-MS to analyse enzymatically digested glycosaminoglycans.

@article{Karlsson2005UseOG,
  title={Use of graphitised carbon negative ion LC-MS to analyse enzymatically digested glycosaminoglycans.},
  author={Niclas G. Karlsson and Benjamin L Schulz and Nicolle H. Packer and John M Whitelock},
  journal={Journal of chromatography. B, Analytical technologies in the biomedical and life sciences},
  year={2005},
  volume={824 1-2},
  pages={
          139-47
        }
}
Capillary liquid chromatography-mass spectrometry using graphitised carbon stationary phase and ion trap mass spectrometry was shown to be a powerful technique for analysing glycosaminoglycans digested with endoglycosidases. Commonly found disaccharides from heparin/heparan sulphate digests at sub nanomole levels were found to be separated by mass and/or retention time and detected by negative ion electrospray mass spectrometry predominantly as [M-H]- ions using a standard electrospray… CONTINUE READING

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