Use of genomics and combinatorial chemistry in the development of new antimycobacterial drugs.

@article{Barry2000UseOG,
  title={Use of genomics and combinatorial chemistry in the development of new antimycobacterial drugs.},
  author={Clifton E Barry and Richard A. Slayden and Alan Sampson and Richard E. Lee},
  journal={Biochemical pharmacology},
  year={2000},
  volume={59 3},
  pages={221-31}
}
With the completion of the genome of Mycobacterium tuberculosis comes the promise of a new generation of potent drugs to combat the emerging epidemic of multiply drug-resistant isolates. Translating this genomic information into realistic assays, valid targets, and preclinical drug candidates represents the next great hope in tuberculosis control. We propose a paradigm for exploiting the genome to inform the development of novel antituberculars, utilizing the techniques of differential gene… CONTINUE READING

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