Use of genome selected repeated sequences increases the sensitivity of PCR detection of Tropheryma whipplei.

@article{Fnollar2004UseOG,
  title={Use of genome selected repeated sequences increases the sensitivity of PCR detection of Tropheryma whipplei.},
  author={Florence F{\'e}nollar and P C Fournier and Catherine Robert and Didier Raoult},
  journal={Journal of clinical microbiology},
  year={2004},
  volume={42 1},
  pages={401-3}
}
The availability of the Tropheryma whipplei genome offers the putative possibility of choosing logical DNA targets. We applied a PCR assay (targeting repeated sequences of T. whipplei) to samples from patients with Whipple's disease and to those from members of a control group. When compared to the results seen with regular PCR, the sensitivity of repeat PCR was significantly enhanced (P = 0.02) without alteration of its specificity. 

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Quantitative detection of Tropheryma whipplei DNA by real-time PCR

  • F. Fenollar, P. Fournier, R. Gerolami, H. Lepidi, C. Poyart, D. Raoult
  • J. Clin. Microbiol
  • 2002

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