Use of genetically modified muscle and fat grafts to repair defects in bone and cartilage.

  title={Use of genetically modified muscle and fat grafts to repair defects in bone and cartilage.},
  author={Christopher H. Evans and Fang Feng Liu and Vaida Glatt and Judith A Hoyland and C. Kirker-head and Andrew D. Walsh and Oliver Betz and James W. Wells and Volker Betz and R. Michael Porter and Fawzy A. Saad and Louis Charles Gerstenfeld and Thomas A. Einhorn and Mitchel Byron Harris and Mark Steven Vrahas},
  journal={European cells & materials},
We report a novel technology for the rapid healing of large osseous and chondral defects, based upon the genetic modification of autologous skeletal muscle and fat grafts. These tissues were selected because they not only possess mesenchymal progenitor cells and scaffolding properties, but also can be biopsied, genetically modified and returned to the patient in a single operative session. First generation adenovirus vector carrying cDNA encoding human bone morphogenetic protein-2 (Ad.BMP-2… CONTINUE READING
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