Use of fluroquinolone and risk of Achilles tendon rupture: a population-based cohort study

@article{Sode2007UseOF,
  title={Use of fluroquinolone and risk of Achilles tendon rupture: a population-based cohort study},
  author={J Sode and Niels Obel and Jesper Hallas and Annmarie Touborg Lassen},
  journal={European Journal of Clinical Pharmacology},
  year={2007},
  volume={63},
  pages={499-503}
}
ObjectiveSeveral case-control studies have reported that the use of fluoroquinolone increases the risk of rupture of the Achilles tendon. Our aim was to estimate this risk by means of a population-based cohort approach.SettingData on Achilles tendon ruptures and fluoroquinolone use were retrieved from three population-based databases that include information on residents of Funen County (population: 470,000) in primary and secondary care during the period 1991–1999. A study cohort of all 28,262… 
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TLDR
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TLDR
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TLDR
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TLDR
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TLDR
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Tendon Injury and Fluoroquinolone Use: A Systematic Review
TLDR
Observational studies showed an increased risk of tendon injury, including tendon rupture and tendinitis, with exposure to fluoroquinolone antibiotic therapy, and although this complication appears to be rare, concomitant corticosteroids increase the risk for tendon injury.
Predictors of Primary Achilles Tendon Ruptures
TLDR
There is moderate evidence that decreased tendon fibril size increases the ATR risk and limited evidence for many other factors, some of which are modifiable, such as increased body weight, oral corticosteroid use and quinolone use and living in an urban area, and therefore may be of interest in future studies.
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TLDR
In the Netherlands, a large simultaneous increase in non‐traumatic tendon ruptures and fluoroquinolone use was observed in the period between 1991 to 1996, and the increase in the incidence of non-traumatic hospitalised tendon rupturing in the Netherlands is not likely to be explained solely by the increased use of fluoroquolones.
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TLDR
Current exposure to quinolones increased the risk of Achilles tendon rupture, and the risk is highest among elderly patients who were concomitantly treated with corticosteroids.
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TLDR
The incidence of Achilles tendon ruptures in this community was comparable to those reported in European communities (range 6 to 37 ruptures per 100,000 people), although a bimodal age distribution of rupture previously reported was not observed in this study.
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TLDR
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TLDR
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TLDR
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