Use of fluorescent dyes as molecular probes for the study of multidrug resistance.

@article{Neyfakh1988UseOF,
  title={Use of fluorescent dyes as molecular probes for the study of multidrug resistance.},
  author={Alexander A. Neyfakh},
  journal={Experimental cell research},
  year={1988},
  volume={174 1},
  pages={168-76}
}
Fluorescence microscopy has shown that 18 different fluorescent dyes, staining various intracellular structures in transformed hamster fibroblasts (DM-15), did not stain or stained weakly multidrug-resistant cells selected from DM-15 by colchicine. Reduced staining by fluorescent dyes was characteristic also of five other tested multidrug-resistant cell lines of hamster and mouse origin, selected by actinomycin D, colcemid, rubomycin, and ruboxyl. The intensity of staining of two revertant cell… CONTINUE READING

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