Use of expression data and the CGEMS genome-wide breast cancer association study to identify genes that may modify risk in BRCA1/2 mutation carriers

@article{Walker2007UseOE,
  title={Use of expression data and the CGEMS genome-wide breast cancer association study to identify genes that may modify risk in BRCA1/2 mutation carriers},
  author={Logan C. Walker and Nicola Waddell and Anette ten Haaf and Sean M. Grimmond and Amanda B Spurdle},
  journal={Breast Cancer Research and Treatment},
  year={2007},
  volume={112},
  pages={229-236}
}
Germline mutations in BRCA1 or BRCA2 confer an increased lifetime risk of developing breast or ovarian cancer, but variable penetrance suggests that cancer susceptibility is influenced in part by modifier genes. Microarray expression profiling was conducted for 69 irradiated lymphoblastoid cell lines derived from healthy controls, or from cancer-affected women with a strong family history of breast and ovarian cancer carrying pathogenic mutations in BRCA1 or BRCA2, or with no BRCA1/2 mutations… CONTINUE READING