Use of evolutionary information in the fitting of atomic level protein models in low resolution cryo-EM map of a protein assembly improves the accuracy of the fitting.

Abstract

Protein-protein interface residues, especially those at the core of the interface, exhibit higher conservation than residues in solvent exposed regions. Here, we explore the ability of this differential conservation to evaluate fittings of atomic models in low-resolution cryo-EM maps and select models from the ensemble of solutions that are often proposed… (More)
DOI: 10.1016/j.jsb.2016.07.012

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Cite this paper

@article{Joseph2016UseOE, title={Use of evolutionary information in the fitting of atomic level protein models in low resolution cryo-EM map of a protein assembly improves the accuracy of the fitting.}, author={Agnel Praveen Joseph and L. S. Swapna and Ramachandran Rakesh and Narayanaswamy Srinivasan}, journal={Journal of structural biology}, year={2016}, volume={195 3}, pages={294-305} }