Use of epithelial cell cultures for studies on the mechanism of transformation by chemical carcinogens


Evidence is reviewed for and against four major theories of chemical carcinogenesis. The development of several normal and transformed epithelial cell lines which should be useful for the analysis of this problem is described. The detection of RNA viral particles in cells transformed with chemical carcinogens is a recurrent finding in studies from our own… (More)
DOI: 10.1007/BF02615421

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