Use of endothelium cultured on microcarriers as a model for the microcirculation.

  title={Use of endothelium cultured on microcarriers as a model for the microcirculation.},
  author={Christer Busch and Pasquale A. Cancilla and L E Debault and Jonathan C. Goldsmith and W. Garrett Owen},
  journal={Laboratory investigation; a journal of technical methods and pathology},
  volume={47 5},
The geometry of the vascular system is such that the surface area to volume ratio changes dramatically as a unit volume of blood circulates. Thus, it faces a surface area that is some 1000 times larger in the capillaries than in larger vessels. To approach the in vivo situation an in vitro model for the microcirculation was developed that uses endothelium cultured on microcarrier beads. Details of the culture method are presented. The cultures form confluent monolayers around the beads and… CONTINUE READING


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