Use of doxycycline to decrease the growth rate of abdominal aortic aneurysms: a randomized, double-blind, placebo-controlled pilot study.

@article{Mosorin2001UseOD,
  title={Use of doxycycline to decrease the growth rate of abdominal aortic aneurysms: a randomized, double-blind, placebo-controlled pilot study.},
  author={Martti Mosorin and Jukka Juvonen and Fausto Biancari and Jari Satta and Helj{\"a} Marja Surcel and Maija Leinonen and Pekka Saikku and Tatu Juvonen},
  journal={Journal of vascular surgery},
  year={2001},
  volume={34 4},
  pages={606-10}
}
OBJECTIVE Eradication of Chlamydia pneumoniae infection and inhibition of elastolytic matrix metalloproteinases with doxycycline have been suggested to reduce the growth rates of small abdominal aortic aneurysms (AAA). We designed a study to investigate the efficacy of doxycycline in reducing the expansion of small AAAs. SUBJECTS AND METHODS This was a prospective, double-blind, randomized, placebo-controlled study that was set in a university referral hospital. The study group consisted of… CONTINUE READING
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