Use of diphenylhydantoin sodium to dissociate the effects of procainamide on automaticity and conduction in the normal and arrhythmic heart.

@article{Helfant1967UseOD,
  title={Use of diphenylhydantoin sodium to dissociate the effects of procainamide on automaticity and conduction in the normal and arrhythmic heart.},
  author={R. Helfant and B. Scherlag and A. Damato},
  journal={The American journal of cardiology},
  year={1967},
  volume={20 6},
  pages={
          820-5
        }
}
Abstract The interaction of procainamide and diphenylhydantoin on atrioventricular conduction, intraventricular conduction and automaticity in both the nondigitalized and digitalisintoxicated dog heart was studied. Procainamide slowed both A-V conduction and intraventricular conduction in the nondigitalized and digitalis-intoxicated heart. Both of these effects were reversed by diphenylhydantoin, and in 50 per cent of cases, normal conduction was completely restored. In the complete heart block… Expand
Diphenylhydantoin: pharmacological and clinical use.
  • A. Damato
  • Medicine
  • Progress in cardiovascular diseases
  • 1969
Electrophysiologic properties of procainamide in man.
Suppression of ventricular automaticity by antidysrhythmic agents.
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