Use of decellularized porcine liver for engineering humanized liver organ.

@article{Barakat2012UseOD,
  title={Use of decellularized porcine liver for engineering humanized liver organ.},
  author={Omar Barakat and Shahrzad Abbasi and Gabriela B Rodr{\'i}guez and Jessie Rios and R. Patrick Wood and Claire F. Ozaki and Laurie S Holley and Polly K Gauthier},
  journal={The Journal of surgical research},
  year={2012},
  volume={173 1},
  pages={e11-25}
}
BACKGROUND New bioartificial liver devices are needed to supplement the limited supply of organ donors available for patients with end-stage liver disease. Here, we report the results of a pilot study aimed at developing a humanized porcine liver by transplanting second trimester human fetal hepatocytes (Hfh) co-cultured with fetal stellate cells (Hfsc) into the decellularized matrix of a porcine liver. MATERIAL AND METHODS Ischemic livers were removed from 19 Yorkshire swine. Liver… CONTINUE READING