Use of cyproheptadine to stimulate appetite and body weight gain: A systematic review

@article{Harrison2019UseOC,
  title={Use of cyproheptadine to stimulate appetite and body weight gain: A systematic review},
  author={Megan E. Harrison and Mark L Norris and Amy Robinson and Wendy Spettigue and Morgan Morrissey and Leanna Isserlin},
  journal={Appetite},
  year={2019},
  volume={137},
  pages={62-72}
}
Safety of Cyproheptadine, an Orexigenic Drug. Analysis of the French National Pharmacovigilance Data-Base and Systematic Review
Objectives: Cyproheptadine is a first-generation H1-antihistamine drug first that was distributed in the 1960s. While its orexigenic effect was observed early, cyprohepatdine is not yet authorized
Appetite stimulants for patients with cancer: current evidence for clinical practice.
TLDR
Currently, there is no current standard of care for patients with cancer-related anorexia, and international guidelines recommend promoting anabolism through nutritional, physical, and pharmacologic therapies.
Effects of cyproheptadine on body weight gain in children with nonorganic failure to thrive in Taiwan: A hospital-based retrospective study
TLDR
The findings underscore the positive association between cyproheptadine hydrochloride treatment and weight gain among prepubertal children and further prospective clinical studies with a longer and consistent treatment course are warranted.
Apetamin Hepatotoxicity: Potential Consequences of Purchasing a Body Enhancement Drug Off the Internet
TLDR
A 40-year-old previously healthy woman presented with fatigue, right-sided abdominal discomfort, and jaundice 6 weeks after starting Apetamin, which she learned from social media for figure augmentation, causing drug-induced autoimmune hepatitis.
A randomised, double blind, placebo-controlled trial of megestrol acetate or dexamethasone in treating symptomatic anorexia in people with advanced cancer
TLDR
There was no difference in groups between the three arms, with no benefit seen over placebo with anorexia improving in all arms.
Effect and Mechanism of Herbal Medicines on Cisplatin-Induced Anorexia
TLDR
Herbal medicines could be considered a useful treatment method for cisplatin-induced anorexia, as the roles of serotonin and its receptors, cytokines, white blood cells, ghrelin, and leptin were investigated.
[Avoidant/Restrictive Food Intake Disorder (ARFID): What the pediatrician should know].
TLDR
The purpose of this review is to clarify diagnostic criteria and to describe targeted management and treatment interventions with a multidisciplinary approach, without deepening on the treatment of organic medical causes.
Treatment Needs and Rates of Mental Health Comorbidity in Adolescent Patients With ARFID
TLDR
The experiences gained from this pilot study highlight the need for specialized resources for assessment and treatment of patients with ARF ID, the importance of a multidisciplinary approach to treatment, and the necessity of utilization of ARFID-specific measures for program evaluation purposes.
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Long‐term trial of cyproheptadine as an appetite stimulant in cystic fibrosis
TLDR
CH appears to be an effective appetite stimulant in CF, and generally maintains its effect over time with an acceptable side‐effect profile.
A chart review of cyproheptadine for stimulant-induced weight loss.
TLDR
It is concluded that concomitant cyproheptadine may be useful in youths with attention deficit hyperactivity disorder for stimulant-induced weight loss, pending future randomized controlled trials.
Beneficial Effect of Cyproheptadine on Body Mass Index in Undernourished Children: A Randomized Controlled Trial
TLDR
A significant higher body mass index was observed among CH-treated patients after 8 weeks intervention with cyproheptadine compared with the control group (P<0.041).
A randomized, double-blind, placebo-controlled trial of cyproheptadine for appetite stimulation in cystic fibrosis.
TLDR
Use of cyproheptadine in cystic fibrosis patients was well tolerated, showing a significant weight gain and a significant increase in BMI after 12 weeks, and a clinically relevant effect size for weight/age (z score) and body mass index for age (Z score) was found.
APPETITE STIMULATING PROPERTIES OF CYPROHEPTADINE.
  • S. Bergen
  • Medicine
    American journal of diseases of children
  • 1964
TLDR
A study was undertaken in a group of chronically hospitalized asthmatic children at the Asthmatic Unit of St. Luke's Convalescent Hospital for the possible effect of drug induced hypoglycemia as the cause of hyperphagia and thus weight gain, and the effect of this agent on carbohydrate tolerance.
A controlled trial of cyproheptadine in cancer patients with anorexia and/or cachexia
TLDR
A randomized, placebo‐controlled, double‐blinded clinical trial using cyproheptadine, 8 mg orally three times a day in 295 patients with advanced malignant disease found that it did not significantly abate progressive weight loss.
Cyproheptadine is an effective appetite stimulant in cystic fibrosis
TLDR
In conclusion, cyproheptadine hydrochloride appears to be an effective appetite stimulant with minimal side effects in children and adults with CF.
Megestrol Acetate Vs Cyproheptadine in the Treatment of Weight Loss Associated with HIV Infection
TLDR
Two appetite stimulants, megestrol acetate and cyproheptadine were administered in a randomized trial to 14 patients who had no evidence of opportunistic infection or malabsorption but were wasted as a result of human immunodeficiency virus (HIV) infection.
The Effect of Cyproheptadine Hydrochloride (Periactin) and Megestrol Acetate (Megace) on Weight in Children With Cancer/Treatment-related Cachexia
TLDR
This study demonstrates that CH is a safe and effective way to promote weight gain in children with cancer/treatment-related cachexia.
Use of Cyproheptadine in Young Children With Feeding Difficulties and Poor Growth in a Pediatric Feeding Program
TLDR
In the experience, the use of cyproheptadine in combination with a specialized multidisciplinary interventional program is a safe and effective therapy in infants and young children with low appetite and poor growth.
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