Use of cyclophosphamide as a positive control in dominant lethal and micronucleus assays.

@article{Krishna1995UseOC,
  title={Use of cyclophosphamide as a positive control in dominant lethal and micronucleus assays.},
  author={G. Gandhi Krishna and J A Petrere and Jeff Anderson and Joachim Thei\ss},
  journal={Mutation research},
  year={1995},
  volume={335 3},
  pages={331-7}
}
Analyses of dominant lethal (DL) mutations and micronuclei (MN) are 2 important and widely used genotoxicity assays to measure drug-induced chromosome damage in germ cells and somatic cells, respectively. Cyclophosphamide (CP) has been widely used as a positive control in the single-dose mouse MN assay; however, its utility as a positive control for the DL assay has not been fully studied. In the present study, CP was tested in both assays under similar experimental conditions and MN seen in… CONTINUE READING

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