Use of cyclohexanedimethanol as a nonflammable organic solvent for industrial scale reversed phase chromatography.


This work demonstrates that cyclohexanedimethanol is an effective nonflammable organic solvent for the pilot scale reversed phase chromatography of recombinant apolipoprotein A-I(Milano). Cyclohexanedimethanol has low viscosity in water, enabling the use of conventional low pressure process scale chromatography columns and hardware. Results from pilot scale… (More)
DOI: 10.1016/j.chroma.2008.06.032