Use of comprehensive screening methods to detect selective human CAR activators.

@article{Kblbeck2011UseOC,
  title={Use of comprehensive screening methods to detect selective human CAR activators.},
  author={Jenni K{\"u}blbeck and Tuomo Laitinen and Johanna Jyrkk{\"a}rinne and Timo Rousu and Ari Tolonen and Tobias Abel and Tanja Kortelainen and Jouko Uusitalo and Timo Korjamo and Paavo Honkakoski and Ferdinand Moln{\'a}r},
  journal={Biochemical pharmacology},
  year={2011},
  volume={82 12},
  pages={1994-2007}
}
The so-called human xenosensors, constitutive androstane receptor (hCAR), pregnane X receptor (hPXR) and aryl hydrocarbon receptor (hAhR), participate in drug metabolism and transport as well as in several endogenous processes by regulating the expression of their target genes. While the ligand specificities for hPXR and hAhR are relatively well described, this property of hCAR still remains fairly unclear. Identifying hCAR agonists for drug development and for studying hCAR biology are… CONTINUE READING