Use of combined Gn-RH agonist and hGH therapy for better attining the goals in precocious puberty treatment.

@article{Tat1995UseOC,
  title={Use of combined Gn-RH agonist and hGH therapy for better attining the goals in precocious puberty treatment.},
  author={Luciano Tat{\`o} and Giuseppe Saggese and L. Cavallo and Franco Antoniazzi and Andrea Corrias and Anna Maria Pasquino and Mariangela Cisternino},
  journal={Hormone research},
  year={1995},
  volume={44 Suppl 3},
  pages={49-54}
}
We studied 30 girls (age 6.36 +/- 1.21 years, range 4.6-8.8) affected by idiopathic precocious puberty with significant reduction of height velocity (below the 25th centile) at the end of 1 year of Gn-RHa (triptorelin intramuscular depot) treatment, to evaluate GH-IGF-I axis activity and the effects of combined Gn-RHa plus hGH therapy. After 12 months, 15 patients continued Gn-RHa and started hGH therapy for 12 months, while 15 continued treatment with Gn-RHa alone (control group). We evaluated… CONTINUE READING

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