• Chemistry, Medicine
  • Published in
    Journal of pharmaceutical…
    2007
  • DOI:10.1002/jps.20855

Use of chitosan-alginate as alternative pelletization aid to microcrystalline cellulose in extrusion/spheronization.

@article{Charoenthai2007UseOC,
  title={Use of chitosan-alginate as alternative pelletization aid to microcrystalline cellulose in extrusion/spheronization.},
  author={Nattawut Charoenthai and Peter Kleinebudde and Satit Puttipipatkhachorn},
  journal={Journal of pharmaceutical sciences},
  year={2007},
  volume={96 9},
  pages={
          2469-84
        }
}
Two types of different molecular weight chitosan were investigated as a pelletization aid in extrusion/spheronization using water as granulation liquid. Spherical pellets with a maximum fraction of 60% w/w chitosan could be produced when 1.25-2.5% w/w sodium alginate was included in the formulations with no microcrystalline cellulose (MCC). Chitosan with lower molecular weight of 190 kDa showed a better pellet forming property. The pellets obtained had acceptable physical characteristics and a… CONTINUE READING

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