Use of carbon monoxide as a therapeutic agent: promises and challenges

@article{Foresti2008UseOC,
  title={Use of carbon monoxide as a therapeutic agent: promises and challenges},
  author={Roberta Foresti and Mohamed G Bani-Hani and Roberto Motterlini},
  journal={Intensive Care Medicine},
  year={2008},
  volume={34},
  pages={649-658}
}
As a by-product of heme catabolism by the heme oxygenase system, carbon monoxide (CO) has been neglected for many years, and only recently has its role as an essential signaling molecule been appreciated. In the past decade, the use of CO gas in pre-clinical experimental models of disease has produced some remarkable data indicating that its therapeutic delivery to mammals could alleviate inflammatory processes and cardiovascular disorders. However, the inherent toxic nature of CO cannot be… 
Therapeutic Applications of Carbon Monoxide
TLDR
The aim of this review is to discuss the potential therapeutic implications of CO with a focus on lung injury and sepsis-related models and co-treatment and post-treatment with CO.
Aspects of Carbon Monoxide in Form of CO-Releasing Molecules Used in Cancer Treatment: More Light on the Way
TLDR
An overview of the research focused on the role of CO and CORMs in different types of cancer and the recent development of the next generation CORMs for clinical application in cancer treatment are given.
The therapeutic potential of carbon monoxide
TLDR
An overview of the physiology of CO is provided, the effects of CO gas and CO-releasing molecules in preclinical animal models of cardiovascular disease, inflammatory disorders and organ transplantation are summarized, and the development and therapeutic options for the exploitation of this simple gaseous molecule are discussed.
Therapeutic Potential of Heme Oxygenase-1/Carbon Monoxide in Lung Disease
TLDR
Salutary effects of the HO-1/CO system have been demonstrated in lung inflammation/acute lung injury, lung and vascular transplantation, sepsis, and pulmonary hypertension models and suggest that the regulation of autophagy and the preservation of mitochondrial homeostasis may serve as additional candidate mechanisms.
Bench-to-bedside review: Carbon monoxide – from mitochondrial poisoning to therapeutic use
TLDR
Differences in bioavailability of endogenous CO production and exogenous CO supplementation might also provide an explanation for the lack of protective effects observed in some experimental and clinical studies.
Therapeutic potential of carbon monoxide in multiple sclerosis
TLDR
The accumulating data discussed herein support the possibility that CORMs may represent a novel class of drugs with disease‐modifying properties in multiple sclerosis.
Carbon monoxide: present and future indications for a medical gas
TLDR
The development of chemical CO releasing compounds constitutes a novel pharmaceutical approach to CO delivery with demonstrated effectiveness in sepsis models, and current and pending clinical evaluation will determine the usefulness of this gas as a therapeutic in human disease.
Carbon Monoxide: An Essential Signalling Molecule
TLDR
This review examines the research involving the development of classes of compounds (with particular emphasis on metal carbonyls) that release CO, which could be used in clinically relevant conditions and draws from published papers in the chemical literature but also from the extensive biological literature and patents on CO-releasing molecules (CO-RMs).
Carbon monoxide in intensive care medicine—time to start the therapeutic application?!
TLDR
The current understanding of carbon monoxide’s biology and its possible organ targets to treating the critically ill patients in tomorrow's ICU are summarized.
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 98 REFERENCES
Therapeutic applications of carbon monoxide-releasing molecules
TLDR
A novel class of substances, CO-releasing molecules (CO-RMs), which are capable of exerting a variety of pharmacological activities via the liberation of controlled amounts of CO in biological systems are identified.
Carbon monoxide: innovative anti-inflammatory properties of an age-old gas molecule.
  • L. Otterbein
  • Chemistry, Medicine
    Antioxidants & redox signaling
  • 2002
TLDR
CO at low concentrations, concentrations that are well below those that would otherwise create toxic effects, is proving beneficial in models of acute injury and is proving to be an extraordinary signaling molecule generated by the cell that is vital in the regulation of cellular homeostasis.
Carbon monoxide-releasing molecules (CO-RMs) modulate respiration in isolated mitochondria.
TLDR
The results indicate that HO-1 induction and enhanced CO decrease renal oxygen consumption and alter mitochondrial function suggesting that CO could be a physiological regulator of mitochondrial oxidative phosphorylation.
Heme oxygenase-1/carbon monoxide: from basic science to therapeutic applications.
TLDR
The molecular and biochemical characterization of HOs is reviewed, with a discussion on the mechanisms of signal transduction and gene regulation that mediate the induction of HO-1 by environmental stress, to lay a foundation for potential future clinical applications of these systems.
Carbon monoxide in biology and medicine
  • S. Ryter, L. Otterbein
  • Biology, Medicine
    BioEssays : news and reviews in molecular, cellular and developmental biology
  • 2004
TLDR
The biological significance and medical applications of CO, a product of organic oxidation processes, arises in vivo during cellular metabolism, most notably heme degradation, and can modulate numerous pathophysiological states.
Carbon Monoxide-Releasing Molecules: Characterization of Biochemical and Vascular Activities
TLDR
It is reported that a series of transition metal carbonyls, termed here carbon monoxide-releasing molecules (CO-RMs), liberate CO to elicit direct biological activities and caused sustained vasodilation in precontracted rat aortic rings, attenuated coronary vasoconstriction in hearts ex vivo, and significantly reduced acute hypertension in vivo.
Protective effect of carbon monoxide in transplantation
During the last decades due to the development of new immunosuppressive agents and improvements in organ preservation methods, surgical techniques, and postoperative care, organ transplantation has
Biological chemistry of carbon monoxide.
  • C. Piantadosi
  • Chemistry, Medicine
    Antioxidants & redox signaling
  • 2002
TLDR
A brief update on the biochemistry of CO as it relates to Hp binding, chemical oxidative processes, and cellular function is provided.
The clinical toxicology of carbon monoxide.
CORM‐A1: a new pharmacologically active carbon monoxide‐releasing molecule
  • R. Motterlini, P. Sawle, +4 authors C. Green
  • Chemistry, Medicine
    FASEB journal : official publication of the Federation of American Societies for Experimental Biology
  • 2005
TLDR
The results reveal that the bioactivities exerted by CORM‐A1 reflect its intrinsic biochemical behavior of a slow CO releaser, which may be advantageous in the treatment of chronic conditions that require CO to be delivered in a carefully controlled manner.
...
1
2
3
4
5
...