Use of carbon monoxide as a therapeutic agent: promises and challenges

  title={Use of carbon monoxide as a therapeutic agent: promises and challenges},
  author={Roberta Foresti and M. G. Bani-Hani and R. Motterlini},
  journal={Intensive Care Medicine},
  • Roberta Foresti, M. G. Bani-Hani, R. Motterlini
  • Published 2008
  • Medicine
  • Intensive Care Medicine
  • As a by-product of heme catabolism by the heme oxygenase system, carbon monoxide (CO) has been neglected for many years, and only recently has its role as an essential signaling molecule been appreciated. In the past decade, the use of CO gas in pre-clinical experimental models of disease has produced some remarkable data indicating that its therapeutic delivery to mammals could alleviate inflammatory processes and cardiovascular disorders. However, the inherent toxic nature of CO cannot be… CONTINUE READING
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