Use of c-KIT/PDGFRA mutational analysis to predict the clinical response to imatinib in patients with advanced gastrointestinal stromal tumours entered on phase I and II studies of the EORTC Soft Tissue and Bone Sarcoma Group.

@article{DebiecRychter2004UseOC,
  title={Use of c-KIT/PDGFRA mutational analysis to predict the clinical response to imatinib in patients with advanced gastrointestinal stromal tumours entered on phase I and II studies of the EORTC Soft Tissue and Bone Sarcoma Group.},
  author={Maria Debiec-Rychter and Herlinde Dumez and Ian Judson and Bartosz Wasąg and Jos Verweij and Myles Brown and Sa{\vs}a Dimitrijevi{\'c} and Ralf Sciot and Michel Stul and H Vranck and Michelle Scurr and Anna Hagemeijer and M van Glabbeke and Allan T. van Oosterom},
  journal={European journal of cancer},
  year={2004},
  volume={40 5},
  pages={689-95}
}
Previous studies have shown that activating mutations of c-KIT/PDGFRA, potential therapeutic targets for imatinib mesylate, are implicated in the pathophysiology of gastrointestinal stromal tumours (GISTs). In this study, GISTs from 37 patients enrolled in an European Organisation for Research and Treatment of Cancer (EORTC) phase I/II clinical study of imatinib were examined for mutations of c-KIT/PDGFRA in order to explore whether the mutational status of the tumour predicts the clinical… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 174 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 19 references

Mechanisms of resistance to imatinib mesylate (IM) in advanced gastrointestinal stromal tumot (GIST)

  • JA Fletcher, CL Corless, S Dimitrijevic
  • Proc Am Soc Clin Oncol,
  • 2003
1 Excerpt

PDGFRA and KIT mutations correlate with the clinical responses to imatinib mesylate in patients with advanced gastrointestinal stromal tumors (GIST)

  • MC Heinrich, CL Corless, M Von Mehren
  • Proc Am Soc Clin Oncol,
  • 2003
3 Excerpts

Efficacy and safety of Imatinib mesylate in advanced gastrointestinal stromal tumors

  • GD Demetri, M von Mehren, CD Blanke
  • New Eng J Med
  • 2002
1 Excerpt

Similar Papers

Loading similar papers…