Use of buprenorphine in the treatment of opiate addiction. I. Physiologic and behavioral effects during a rapid dose induction.

Abstract

A new, rapid dose-induction procedure was used in the evaluation of buprenorphine hydrochloride (buprenorphine) as a treatment for opiate dependence. Nineteen heroin-dependent men were given buprenorphine sublingually in ascending daily doses of 2, 4, and 8 mg and then maintained on 8 mg daily. The observations of the transition from heroin to buprenorphine… (More)

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@article{Johnson1989UseOB, title={Use of buprenorphine in the treatment of opiate addiction. I. Physiologic and behavioral effects during a rapid dose induction.}, author={R. E. Johnson and Edward J. Cone and J. E. Henningfield and Paul J. Fudala}, journal={Clinical pharmacology and therapeutics}, year={1989}, volume={46 3}, pages={335-43} }