Use of botulinum toxin in anal fissure

@article{Jost1993UseOB,
  title={Use of botulinum toxin in anal fissure},
  author={W. Jost and K. Schimrigk},
  journal={Diseases of the Colon & Rectum},
  year={1993},
  volume={36},
  pages={974}
}
To the Ed i to r Impor t an t in the origin of a chronic fissure is the vicious circle of inflammation, pain, and sphincter spasm. 1 Medical managemen t can tackle the inf lammation and the pain and, hence , the spasm. Anal dilation, like lateral sphincterotomy acts by a direct reduct ion in anal tone; posterior sph inc te ro tomy by removal of the ulcer and the secondary changes as well as causing a reduction in tone. We investigated a new mode of therapy involving injection of the external… Expand
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