Use of bomb pulse carbon-14 to age senile plaques and neurofibrillary tangles in Alzheimer's disease.

@article{Lovell2002UseOB,
  title={Use of bomb pulse carbon-14 to age senile plaques and neurofibrillary tangles in Alzheimer's disease.},
  author={Mark A Lovell and J. David Robertson and Bruce A. Buchholz and Chengsong Xie and William R. Markesbery},
  journal={Neurobiology of aging},
  year={2002},
  volume={23 2},
  pages={179-86}
}
The time course of formation of neurofibrillary tangles (NFT) and senile plaques (SP) in Alzheimer's disease (AD) brain is unknown. Above ground nuclear weapons testing in the late 1950s and early 1960s led to significantly increased levels of 14C in the atmosphere and carbon cycle. Because the amyloid beta peptide of SP and paired helical filaments of NFT, once formed, are relatively resistant to degradation, 14C levels observed in SP and NFT should reflect their year of formation. The purpose… CONTINUE READING

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