Use of biotin targeted methotrexate–human serum albumin conjugated nanoparticles to enhance methotrexate antitumor efficacy

@inproceedings{Taheri2011UseOB,
  title={Use of biotin targeted methotrexate–human serum albumin conjugated nanoparticles to enhance methotrexate antitumor efficacy},
  author={Azade Taheri and Rassoul Dinarvand and Faranak Salman Nouri and Mohammad Reza Khorramizadeh and Atefeh Taheri Borougeni and Pooria Mansoori and Fatemeh Atyabi},
  booktitle={International journal of nanomedicine},
  year={2011}
}
Biotin molecules could be used as suitable targeting moieties in targeted drug delivery systems against tumors. To develop a biotin targeted drug delivery system, we employed human serum albumin (HSA) as a carrier. Methotrexate (MTX) molecules were conjugated to HSA. MTX-HSA nanoparticles (MTX-HSA NPs) were prepared from these conjugates by cross-linking… CONTINUE READING