Use of bifunctional ureas to increase the rate of proline-catalyzed alpha-aminoxylations.


The rate of the proline-catalyzed alpha-aminoxylation of aldehydes is significantly increased in the presence of a bifunctional urea. Structure-activity relationship data indicate that both an amine and a urea are crucial for rate enhancement. The evidence presented herein suggests that this rate enhancement originates from the hydrogen bonding interaction… (More)
DOI: 10.1021/jo802461w


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