Use of bicarbonate buffer systems for dissolution characterization of enteric-coated proton pump inhibitor tablets.


OBJECTIVES The aim of this study was to assess the effects of buffer systems (bicarbonate or phosphate at different concentrations) on the in vitro dissolution profiles of commercially available enteric-coated tablets. METHODS In vitro dissolution tests were conducted using an USP apparatus II on 12 enteric-coated omeprazole and rabeprazole tablets… (More)
DOI: 10.1111/jphp.12540