Use of asthma control indicators in measuring inhaled corticosteroid effectiveness in asthmatic smokers: a systematic review

  title={Use of asthma control indicators in measuring inhaled corticosteroid effectiveness in asthmatic smokers: a systematic review},
  author={Claire E. Hayes and Henry Nuss and Tung-Sung Tseng and Sarah Moody-Thomas},
  journal={Journal of Asthma},
  pages={1005 - 996}
Abstract Objective: The objective of this review is to explore how current research measures the effectiveness of inhaled corticosteroids (ICS) in smokers with asthma. Data sources: PubMed, CINAHL and PsycINFO databases were searched for combinations of terms relating to asthma, tobacco use and ICS effectiveness. Study selections: The search was limited to articles published between 2004 and 2015, in English language. Studies met inclusion criteria if reporting the use of guideline-based asthma… 
Challenges in the management of asthma associated with smoking-induced airway diseases
  • N. Thomson
  • Medicine, Biology
    Expert opinion on pharmacotherapy
  • 2018
Evidence for the efficacy of small molecule drugs used in the clinic to treat current and former smokers with a diagnostic label of asthma or ACO is summarized and preliminary findings suggest that low-dose theophylline, statins, and biologics, such as omalizumab, mepolizumAB, and dupilumab may improve clinical outcomes in smokers with asthma orACO.
Consensus document on asthma and smoking of the Regional Asthma Forum of SEPAR.
A narrative review of the literature was carried out for consensus using a nominal group methodology developed throughout 2019 to extract practical recommendations that would allow the diagnosis and treatment of asthma in smokers, as well as the treatment of smoking in asthmatics, to be improved.
Health beliefs associated with poor disease self-management in smokers with asthma and/or COPD: a pilot study
The health beliefs of smokers may influence their self-management behaviors and can inform the development of services that target smokers in order to improve adherence to self- management behaviors and health outcomes.
Self-management practices of smokers with asthma and/or chronic obstructive pulmonary disease: a cross-sectional survey
By identifying self-management practices that are most difficult for smokers to follow, researchers can develop interventions that target these behaviors.
Inhaled corticosteroids do not reduce initial high activity of matrix metalloproteinase (MMP)-9 in exhaled breath condensates of children with asthma exacerbation: a proof of concept study
The data suggest that ICS, although sufficient to control symptoms and inflammatory markers, may be ineffective to reduce MMP-9/EBC activity in asthma exacerbation and, possibly, airway remodeling.
Expression and pathological significance of CC chemokine receptor 7 and its ligands in the airway of asthmatic rats exposed to cigarette smoke.
Cigarette smoking may aggravate asthma symptoms by attenuating immunity, possibly through CCR7-mediated DCs aggregation in lung tissue.
miR-135a inhibits airway inflammatory response in asthmatic mice via regulating JAK/STAT signaling pathway.
The inhibitory effect of miR-135a in regulating JAK/STAT signaling pathway on airway inflammation in asthmatic mice was investigated and the airway hyperresponsiveness of the mice was significantly decreased after treatment with the miR/STAT agonist.


Smoking influences response to inhaled corticosteroids in patients with asthma: a meta-analysis
Smoking is associated with attenuated response to inhaled corticosteroids in asthmatics, which offers a rationale for persuasion of smoking cessation and treatment outcomes might be improved by smoking cessation leading to improved lung function and ameliorated symptoms.
Integrating Evidence for Managing Asthma in Patients Who Smoke
Exploratory studies of possible treatment options for smoking asthma suggest potential utility in prescribing higher-dose ICS; targeting the small airways of the lungs with extra-fine particle ICS formulations; targeting leukotreines; and possibly also combinations of these options.
Inhaled corticosteroids and decline of lung function in community residents with asthma
Treatment with ICS is associated with a significantly reduced decline in ventilatory function, and adjustment for additional variables including age, socioeconomic status, body mass index, mucus hypersecretion, and use of other asthma medications did not change these results.
Influence of cigarette smoking on inhaled corticosteroid treatment in mild asthma
Active cigarette smoking impairs the efficacy of short term inhaled corticosteroid treatment in mild asthma, and this finding has important implications for the management of patients with mild asthma who smoke.
Lung function decline in asthma: association with inhaled corticosteroids, smoking and sex
Treatment with ICS in adult patients with moderate to severe asthma was associated with a reduction in the decline in FEV1 over a 23 year follow up period in men who had smoked <5 pack years, and this effect was dose dependent and was not present in women or in men with ⩾5Pack years of smoking at follow up.
The value of self-report assessment of adherence, rhinitis and smoking in relation to asthma control.
Poor asthma control is associated with self-reported rhinitis, smoking and low medication adherence, and these potentially modifiable predictors of poor asthma control can be identified through a brief self-report questionnaire.
The effects of inhaled budesonide on lung function in smokers and nonsmokers with mild persistent asthma.
Asthmatic patients who smoke, and are not treated with ICSs, have a greater decline in lung function than asthmatic Patients who do not smoke and the benefits of therapy with inhaled budesonide on preventing lung function decline are similar in smokers and nonsmokers with mild persistent asthma.
Protocol: Influence of Budesonide and Budesonide/Formoterol on Asthma Control in Smoking Asthmatic Adults
No significant differences were found between smoking and non-smoking subjects with mild asthma in regard to clinical changes in asthma control, pulmonary function and airway inflammation following a 2-month treatment period with budesonide or the association of budesonides and formoterol for a period of 2 months.
Smoking affects response to inhaled corticosteroids or leukotriene receptor antagonists in asthma.
In subjects with mild asthma who smoke, the response to inhaled corticosteroids is attenuated, suggesting that adjustments to standard therapy may be required to attain asthma control.
Efficacy of low and high dose inhaled corticosteroid in smokers versus non-smokers with mild asthma
Compared with non-smokers, smokers with mild persistent asthma are insensitive to the therapeutic effect of low dose inhaled corticosteroid treatment administered for a 12 week period.