Use of association studies to define genetic modifiers of breast cancer risk in BRCA1 and BRCA2 mutation carriers

@article{Hughes2008UseOA,
  title={Use of association studies to define genetic modifiers of breast cancer risk in BRCA1 and BRCA2 mutation carriers},
  author={David J. Hughes},
  journal={Familial Cancer},
  year={2008},
  volume={7},
  pages={233-244}
}
  • D. Hughes
  • Published 19 February 2008
  • Biology
  • Familial Cancer
Though much progress has been made in understanding the role of two major high-risk breast cancer (BC) susceptibility genes, BRCA1 and BRCA2, it remains unclear what causes the observed variation in risk between mutation carriers. This marked variability in individual cancer risk both between and within BRCA1 and BRCA2 mutation carrier families may be partly explained by modifier genes that influence mutation penetrance. Defining these modifiers should help refine individual cancer risk… 

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