Use of artificial cell microcapsule containing thalidomide for treating TNBS-induced Crohn's disease in mice.

@article{Fakhoury2014UseOA,
  title={Use of artificial cell microcapsule containing thalidomide for treating TNBS-induced Crohn's disease in mice.},
  author={Marc Fakhoury and Michael J. Coussa-Charley and Hani Al-Salami and Imen Kahouli and Satya Prakash},
  journal={Current drug delivery},
  year={2014},
  volume={11 1},
  pages={146-53}
}
In this study, we examined the in-vivo characteristics of a novel microencapsulated thalidomide formulation in a murine model of experimental Crohn's disease. Crohn's disease was induced with a single intra-colonic injection of 120 mg/kg of bodyweight of 2,5,6-trinitrobenzene sulfonic acid (TNBS) dissolved in 30% ethanol in Balb/c mice. Level of tumor… CONTINUE READING