Use of aromatase inhibitors to increase final height

@article{Dunkel2006UseOA,
  title={Use of aromatase inhibitors to increase final height},
  author={Leo Dunkel},
  journal={Molecular and Cellular Endocrinology},
  year={2006},
  volume={254},
  pages={207-216}
}
  • L. Dunkel
  • Published 25 July 2006
  • Medicine, Biology
  • Molecular and Cellular Endocrinology
Aromatase inhibitors in pediatrics
TLDR
Although aromatase inhibitors appear effective in increasing adult height of boys with short stature and/or pubertal delay, safety concerns, including vertebral deformities, a decrease in serum HDL cholesterol levels and increase of erythrocytosis, are reasons for caution.
The use of aromatase inhibitors in boys with short stature: what to know before prescribing?
TLDR
It is important to understand the pharmacokinetics of AIs, recognizing and avoiding possible drug interactions and offering a safer prescription profile of this class of aromatase inhibitors.
Aromatase Inhibitors to Augment Height: Continued Caution and Study Required
  • M. Geffner
  • Biology
    Journal of clinical research in pediatric endocrinology
  • 2009
TLDR
It is imperative that there be well-designed, long-term studies of efficacy and safety of AI use in pediatric populations, because little is known about the short- and long- term safety of AIs in children.
Use of Aromatase Inhibitors in Children and Adolescents With Disorders of Growth and Adolescent Development
Although treatment of children and adolescents who have disorders of growth and adolescent development with aromatase inhibitors is increasingly common, data for or against their use are extremely
Aromatase research and its clinical significance Znaczenie kliniczne badań nad aromatazą
TLDR
Researchers contributed to the development of aromatase inhibitors (AIs), an effective and safe group of drugs for the first-line endocrine therapy of breast cancer, to establish AIs application in other oestrogen-dependent conditions, and to overcome the resistance in breast cancer patients.
History of aromatase: saga of an important biological mediator and therapeutic target.
TLDR
The saga of these studies of aromatase and the ultimate utilization of inhibitors as highly effective treatments of breast cancer and for use in reproductive disorders serves as the basis for this first Endocrine Reviews history manuscript.
Alternative Strategies for the Treatment of Classical Congenital Adrenal Hyperplasia: Pitfalls and Promises
TLDR
Gene therapy and stem cells, to provide functional adrenal cortical tissue, are at preclinical stage but provide exciting avenues for a potential cure for CAH.
Effect of Anastrozole Treatment on Predicted Adult Height in Prepubertal Boys with Idiopathic Short Stature
TLDR
Anastrozole delays bone maturation and improves PAH in boys with ISS and predicts adult height in Prepubertal Boys with Idiopathic short stature.
Aromatase research and its clinical significance.
TLDR
Researchers contributed to the development of aromatase inhibitors (AIs), an effective and safe group of drugs for the first-line endocrine therapy of breast cancer, to establish AIs application in other oestrogen-dependent conditions, and to overcome the resistance in breast cancer patients.
Bicalutamide and Third-Generation Aromatase Inhibitors in Testotoxicosis
TLDR
The results of longer-term treatment with this combination therapy in 2 boys who demonstrated that it is well tolerated, slows bone-age advancement in the face of continued linear growth, and prevents progression of virilization are presented.
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TLDR
It is concluded that suppressing of estrogen with testolactone was effective therapy, and that more potent and specific inhibitors of aromatase could further improve the treatment of these disorders.
Inhibition of estrogen biosynthesis with a potent aromatase inhibitor increases predicted adult height in boys with idiopathic short stature: a randomized controlled trial.
TLDR
Treatment with the aromatase inhibitor Lz delays bone maturation and improves PAH in boys with idiopathic short stature and no adverse effects on bone mineralization were evident after 2 yr of treatment.
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TLDR
It is concluded that testolactone is an effective treatment of precocious puberty in the McCune-Albright syndrome.
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TLDR
The responses to androgen and estrogen in a man with a novel, homozygous inactivating mutation of cytochrome P-450 aromatase suggest a crucial role of estrogen in skeletal maturation.
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TLDR
The potent estrogen suppressive action and simple dosage regimen of anastrozole suggest it may be advantageous compared to other aromatase inhibitors such as testolactone or anti-estrogens.
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TLDR
1-yr treatment with this new P450 aromatase inhibitor in pubertal boys is unlikely to be associated with any major harmful effect on developing peak bone mass, However, to convincingly exclude such effects, particularly rare or minor ones, will require a study with a larger sample size.
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TLDR
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TLDR
A novel mutation in the CYP19 gene in a sister and brother exhibited the cardinal features of the aromatase deficiency syndrome as recently defined and was reported on.
Inhibition of P450 aromatase enhances gonadotropin secretion in early and midpubertal boys: evidence for a pituitary site of action of endogenous E.
In early pubertal boys, E concentrations are very low. We studied the role and site of action of endogenous E in the regulation of gonadotropin secretion in early and midpubertal boys by inhibiting
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