Use of aprotinin in patients undergoing deep hypothermic circulatory arrest: a review.

@article{HuffmanEgger2003UseOA,
  title={Use of aprotinin in patients undergoing deep hypothermic circulatory arrest: a review.},
  author={Suzanne Huffman-Egger},
  journal={The journal of extra-corporeal technology},
  year={2003},
  volume={35 4},
  pages={
          339-45
        }
}
Hemostatic derangements continue to be a major clinical challenge during thoracic aortic surgery using deep hypothermic circulatory arrest despite advances in surgical and pharmacologic therapy. Aprotinin, a broad-based, nonspecific serine protease inhibitor has been advocated for prophylactic use in cardiac surgery to decrease perioperative blood loss and blood transfusions. Its efficacy has been documented in several studies throughout the United States and Europe. Currently, aprotinin is… CONTINUE READING

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