Use of antisense oligodeoxynucleotides to study the physiological functions of neuropeptide Y.

@article{Kalra2000UseOA,
  title={Use of antisense oligodeoxynucleotides to study the physiological functions of neuropeptide Y.},
  author={Pushpa S. Kalra and Satya P. Kalra},
  journal={Methods},
  year={2000},
  volume={22 3},
  pages={249-54}
}
Stimulation of appetite and regulation of reproductive hormone secretion are two well-known physiological effects of neuropeptide Y (NPY) that have been affirmed using the antisense oligodeoxynucleotide (ODN) approach. Because NPY-producing neurons are concentrated in a narrow band in the arcuate nucleus of the hypothalamus, ODNs injected intracerebroventricularly have easy access to them. In an early study intracerebroventricular administration of an unmodified phosphodiester ODN sequence… CONTINUE READING
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