Use of antihistamine drugs in early pregnancy and delivery outcome

@article{Klln2002UseOA,
  title={Use of antihistamine drugs in early pregnancy and delivery outcome},
  author={Bengt K{\"a}ll{\'e}n},
  journal={The Journal of Maternal-Fetal \& Neonatal Medicine},
  year={2002},
  volume={11},
  pages={146 - 152}
}
  • B. Källén
  • Published 1 January 2002
  • Medicine
  • The Journal of Maternal-Fetal & Neonatal Medicine
Objective: To study the impact of antihistamine use in early pregnancy on delivery outcome. Methods: Using prospectively collected information on drug use in early pregnancy, delivery outcome was studied among 17 266 women with 17 776 deliveries and 18 197 infants. The analysis was performed according to the main reason for antihistamine use: nausea and vomiting in pregnancy and allergy. Results: In the nausea and vomiting in pregnancy group, we found a significant increase in twin births and a… 

Delivery outcome after the use of meclozine in early pregnancy

Preterm birth, low birth weight, short body length, and small head circumference occurred at a reduced rate after meclozine use, notably for boys, and the rate of congenital malformations was reduced.

Use of antiemetic drugs during pregnancy in Sweden

Women using antiemetics as a rule have a better delivery outcome than other women, probably due to an effect of a well-functioning placenta, which is associated with NVP.

Assessment of antihistamine use in early pregnancy and birth defects.

The Risk of Adverse Pregnancy Outcome After First Trimester Exposure to H1 Antihistamines: A Systematic Review and Meta-Analysis

Based on the meta-analyses, which included a large number of studies, H1 antihistamines are not associated with an increased risk of major malformation or other adverse fetal outcomes.

Use of antihistamine medications during early pregnancy and isolated major malformations.

The results of this study generally were consistent with no association between birth defects and antihistamine use during early pregnancy, although the observed elevated associations should be interpreted in the context of the number of associations investigated and the analysis of retrospective, self-reported data.

Safety of cetirizine in pregnancy

The study suggests that CTZ exposure during pregnancy is not linked to an increase in adverse outcomes, and current evidence indicates that antihistamines are well-tolerated during pregnancy.

Antihistamines and other prognostic factors for adverse outcome in hyperemesis gravidarum.

Use of oral decongestants during pregnancy and delivery outcome.

The safety or risk of antihistamine use in pregnancy: reassuring data are helpful but not sufficient.

  • M. HoneinC. Moore
  • Medicine
    The journal of allergy and clinical immunology. In practice
  • 2013

Antihistamines and birth defects: a systematic review of the literature

A systematic evaluation of the peer-reviewed epidemiologic literature published through February 2014 on the association between prenatal exposure to antihistamines and birth defects finds the positive findings from a few large studies warrant corroboration in other populations.
...

References

SHOWING 1-10 OF 18 REFERENCES

Evaluation of the teratogenic effect of meclizine in man.

A Prospective Study of Drugs and Pregnancy

In a prospective study of anti‐emetic drug use during 6 376 pregnancies, the previously demonstrated negative correlation between the use of such drugs and miscarriage was confirmed and was mainly due to a high incidence of drug use among women giving birth to infants with congenital dislocation of the hip.

Hyperemesis during pregnancy and delivery outcome: a registry study.

  • B. Källén
  • Medicine
    European journal of obstetrics, gynecology, and reproductive biology
  • 1987

Nausea during pregnancy and congenital heart defects: a population-based case-control study.

The results suggest that pregnancy hormones and factors or, alternatively, a component of Bendectin (most probably pyridoxine) may be important for normal heart development and prevention of congenital heart defects.

Nausea and Vomiting in Pregnancy: An Association between Symptoms and Maternal Prostaglandin E2

A positive relationship between NVP and maternal serum PGE2 levels in early pregnancy is shown and is consistent with previous work on this topic.

Nausea and vomiting of early pregnancy and pregnancy outcome. A meta‐analytical review

A statistical meta‐analysis confirmed the decreased risk of miscarriage associated with gestational nausea and vomiting and indicated that the association with decreased fetal mortality was restricted to the first 20 weeks gestation.

Hyperemesis Gravidarum and the Sex of the Offspring

Findings provide evidence that pregnant women with a diagnosis of hyperemesis gravidarum in the first trimester give birth to a higher proportion of female newborns than do all mothers, regardless of whether they are hospitalized.