Use of antidepressants and risk of colorectal cancer: a nested case-control study.

@article{Xu2006UseOA,
  title={Use of antidepressants and risk of colorectal cancer: a nested case-control study.},
  author={W. Xu and H. Tamim and S. Shapiro and M. Stang and J. Collet},
  journal={The Lancet. Oncology},
  year={2006},
  volume={7 4},
  pages={
          301-8
        }
}
BACKGROUND Animal studies suggest that selective serotonin reuptake inhibitors (SSRI) retard the growth of colorectal tumours, whereas tricyclic antidepressants increase the risk of colorectal cancer. We aimed to assess whether SSRI use was associated with a decreased risk of colorectal cancer, and tricyclic-antidepressant use with an increased risk of colorectal cancer. METHODS We did a population-based nested case-control study from Jan 1, 1981, to Dec 31, 2000, of people aged 5-85 years… Expand
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