Use of anti-T-cell monoclonal antibody OKT3 to prevent acute graft-versus-host disease in allogeneic bone-marrow transplantation for acute leukaemia.

@article{Prentice1982UseOA,
  title={Use of anti-T-cell monoclonal antibody OKT3 to prevent acute graft-versus-host disease in allogeneic bone-marrow transplantation for acute leukaemia.},
  author={Hugh Grant Prentice and Hilary A Blacklock and George Janossy and Kenneth F. Bradstock and D. B. L. Skeggs and Gideon Goldstein and Allan Victor Hoffbrand},
  journal={Lancet},
  year={1982},
  volume={1 8274},
  pages={700-3}
}
Seventeen patients who received allogeneic bone-marrow transplants from matched or slightly mismatched (in four patients) siblings were observed for at least 60 days or until acute graft-versus-host disease (GvHD) developed. All donor marrows after preliminary manipulation were incubated with 1 mg of the murine monoclonal antibody OKT3 before infusion in an attempt to deplete them of immunocompetent T lymphocytes (opsonisation). In three of the seventeen patients acute GvHD of grade II or… CONTINUE READING

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