Use of anoctamin 1 (ANO1) to evaluate interstitial cells of Cajal in Hirschsprung’s disease

@article{Coyle2015UseOA,
  title={Use of anoctamin 1 (ANO1) to evaluate interstitial cells of Cajal in Hirschsprung’s disease},
  author={D. Coyle and Danielle Kelly and A. O'donnell and J. Gillick and P. Puri},
  journal={Pediatric Surgery International},
  year={2015},
  volume={32},
  pages={125-133}
}
PurposeInterstitial cells of Cajal (ICCs) are pacemaker cells involved in facilitating neurotransmission and the generation of slow electrical waves necessary for colonic peristalsis. [...] Key Method The distribution of ANO1 and c-kit expression was evaluated using immunofluorescence and confocal microscopy. ANO1 expression was quantified using Western blot analysis.Expand

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