Use of anion-aromatic interactions to position the general base in the ketosteroid isomerase active site.

@article{Schwans2013UseOA,
  title={Use of anion-aromatic interactions to position the general base in the ketosteroid isomerase active site.},
  author={Jason P Schwans and Fanny Sunden and Jonathan Kyle Lassila and Ana Carolina Gonzalez and Yingssu Tsai and Daniel Herschlag},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2013},
  volume={110 28},
  pages={11308-13}
}
Although the cation-pi pair, formed between a side chain or substrate cation and the negative electrostatic potential of a pi system on the face of an aromatic ring, has been widely discussed and has been shown to be important in protein structure and protein-ligand interactions, there has been little discussion of the potential structural and functional importance in proteins of the related anion-aromatic pair (i.e., interaction of a negatively charged group with the positive electrostatic… CONTINUE READING