Use of an oral stable isotope label to confirm variation in red blood cell mean age that influences HbA1c interpretation

  title={Use of an oral stable isotope label to confirm variation in red blood cell mean age that influences HbA1c interpretation},
  author={P. Khera and Eric P. Smith and C. Lindsell and M. Rogge and S. Haggerty and D. Wagner and M. Palascak and Shilpa Mehta and J. Hibbert and C. Joiner and R. Franco and R. Cohen},
  journal={American Journal of Hematology},
HbA1c is commonly used to monitor glycemic control. However, there is growing evidence that the relationship between HbA1c and mean blood glucose (MBG) is influenced by variation in red blood cell (RBC) lifespan in hematologically normal individuals. Correction of HbA1c for mean RBC age (MRBC) requires a noninvasive, accurate, and affordable method to measure RBC survival. In this study, we evaluated whether a stable isotope approach would satisfy these requirements. RBC lifespan and MRBC were… Expand

Paper Mentions

Observational Clinical Trial
Hemoglobin A1C (HbA1c) is the cornerstone of blood sugar monitoring. As HbA1c is formed by the covalent reaction of glucose with hemoglobin throughout the lifespan of the red blood… Expand
ConditionsDiabetes Mellitus, Healthy
InterventionDiagnostic Test
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  • Medicine
  • American journal of hematology
  • 2021
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