Use of an intravenous microdose of 14C-labeled drug and accelerator mass spectrometry to measure absolute oral bioavailability in dogs; cross-comparison of assay methods by accelerator mass spectrometry and liquid chromatography-tandem mass spectrometry.

@article{Miyaji2009UseOA,
  title={Use of an intravenous microdose of 14C-labeled drug and accelerator mass spectrometry to measure absolute oral bioavailability in dogs; cross-comparison of assay methods by accelerator mass spectrometry and liquid chromatography-tandem mass spectrometry.},
  author={Y. Miyaji and T. Ishizuka and K. Kawai and Y. Hamabe and Teiji Miyaoka and T. Oh-hara and T. Ikeda and A. Kurihara},
  journal={Drug metabolism and pharmacokinetics},
  year={2009},
  volume={24 2},
  pages={
          130-8
        }
}
  • Y. Miyaji, T. Ishizuka, +5 authors A. Kurihara
  • Published 2009
  • Chemistry, Medicine
  • Drug metabolism and pharmacokinetics
  • A technique utilizing simultaneous intravenous microdosing of (14)C-labeled drug with oral dosing of non-labeled drug for measurement of absolute bioavailability was evaluated using R-142086 in male dogs. Plasma concentrations of R-142086 were measured by liquid chromatography-tandem mass spectrometry (LC-MS/MS) and those of (14)C-R-142086 were measured by accelerator mass spectrometry (AMS). The absence of metabolites in the plasma and urine was confirmed by a single radioactive peak of the… CONTINUE READING
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