Use of an internal reference for the quantitative HPLC-UV analysis of solid-phase reactions: a case study of 2-chlorotrityl chloride resin.

Abstract

Here we evaluated the use of internal reference compounds for the rapid assessment of reactions performed in solid-phase. An internal reference compound (commercially available) was bound to the resin, together with the substrate, and cleaved with the products after completion of the reaction. The peak area of the reference compound in the HPLC-UV… (More)
DOI: 10.1021/co4000024

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Cite this paper

@article{Spengler2013UseOA, title={Use of an internal reference for the quantitative HPLC-UV analysis of solid-phase reactions: a case study of 2-chlorotrityl chloride resin.}, author={J. -P. Spengler and Anna-Iris Fernandez-Llamazares and Fernando Albericio}, journal={ACS combinatorial science}, year={2013}, volume={15 5}, pages={229-34} }