Use of an aggressive MCF-7 cell line variant, TMX2-28, to study cell invasion in breast cancer.

@article{Gozgit2006UseOA,
  title={Use of an aggressive MCF-7 cell line variant, TMX2-28, to study cell invasion in breast cancer.},
  author={Joseph M. Gozgit and B. T. Pentecost and Sharon A Marconi and Christopher N Otis and Chuanyue Wu and Kathleen F. Arcaro},
  journal={Molecular cancer research : MCR},
  year={2006},
  volume={4 12},
  pages={905-13}
}
An estrogen receptor-negative variant of the MCF-7 breast cancer cell line, TMX2-28, was used as a model in which to study breast cancer cell invasion. Using a reconstituted basement membrane (Matrigel) assay to evaluate cell invasion, we determined that TMX2-28 cells are more invasive than MCF-7 cells and that the invasiveness of TMX2-28 is similar to that of the aggressive MDA-MB-231 breast cancer cell line. TMX2-28 cells displayed a rounded, epithelial cell-like morphology, suggesting an… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 30 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 28 references

Assembly and signaling of adhesion complexes.

Current topics in developmental biology • 2005
View 1 Excerpt

Genomic analysis of a spontaneous model of breast cancer metastasis to bone reveals a role for the extracellular matrix

BL Eckhardt, BS Parker, RK van Laar
Mol Cancer Res • 2005

Mechanisms of cancer cell invasion.

Current opinion in genetics & development • 2005
View 1 Excerpt

Similar Papers

Loading similar papers…