Use of ampicillin/sulbactam versus imipenem/cilastatin in the treatment of limb-threatening foot infections in diabetic patients.

@article{Grayson1994UseOA,
  title={Use of ampicillin/sulbactam versus imipenem/cilastatin in the treatment of limb-threatening foot infections in diabetic patients.},
  author={M Lindsay Grayson and Gary W. Gibbons and G M Habershaw and Dr. Jonathan Freeman and Frank B. Pomposelli and Barry I. Rosenblum and Erik Levin and Adolf W. Karchmer},
  journal={Clinical infectious diseases : an official publication of the Infectious Diseases Society of America},
  year={1994},
  volume={18 5},
  pages={683-93}
}
In a double-blind randomized trial, imipenem/cilastatin (I/C; 500 mg every 6 hours) and ampicillin/sulbactam (A/S; 3 g every 6 hours) were compared in regard to their efficacy for initial empirical and definitive parenteral treatment of limb-threatening pedal infection in diabetic patients. The major endpoints of treatment were cure (resolution of soft-tissue infection), failure (inadequate improvement, necessitating a change in antibiotic therapy), and eradication (clearance of all pathogens… CONTINUE READING

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