Use of amphetamine by recreational users of ecstasy (MDMA) is associated with reduced striatal dopamine transporter densities: a [123I]β-CIT SPECT study – preliminary report

@article{Reneman2001UseOA,
  title={Use of amphetamine by recreational users of ecstasy (MDMA) is associated with reduced striatal dopamine transporter densities: a [123I]β-CIT SPECT study – preliminary report},
  author={L. Reneman and Jan Booij and Jules M. Lavalaye and Kora de Bruin and J. Reitsma and Boudewijn W. Gunning and Gerard J. den Heeten and Wim van den Brink},
  journal={Psychopharmacology},
  year={2001},
  volume={159},
  pages={335-340}
}
Rationale: Tablets sold as ecstasy often contain not only 3,4-methylenedioxymethamphetamine (MDMA) but other compounds well known to cause dopaminergic neurotoxicity, such as (meth)amphetamine. Furthermore, the use of ecstasy in the Netherlands is often combined with the use of amphetamine. However, little is known about the effects of ecstasy use or the combination of ecstasy and amphetamine use on dopamine (DA) neurones in the human brain. Objectives: This study was designed to investigate… CONTINUE READING