Use of allelic loss to predict malignant risk for low-grade oral epithelial dysplasia.

  title={Use of allelic loss to predict malignant risk for low-grade oral epithelial dysplasia.},
  author={Miriam Pearl Rosin and Xiangfei Cheng and Chueh-Loo Poh and Wan L. Lam and Yangbin Huang and Judy Lovas and Ken W. Berean and Joel B. Epstein and Robert W. Priddy and Nhu D. Le and Lewei Zhang},
  journal={Clinical cancer research : an official journal of the American Association for Cancer Research},
  volume={6 2},
One of the best approaches to identifying genetic changes critical to oral cancer progression is to compare progressing and nonprogressing oral premalignant lesions. However, such samples are rare, and they require long-term follow-up. The current study used the large archive network and clinical database in British Columbia to study loss of heterozygosity (LOH) in cases of early oral premalignancies, comparing those with a history of progression to carcinoma in situ or invasive cancer and… CONTINUE READING
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